Significance of regenerating islet-derived type IV gene expression in gastroenterological cancers

Figure 1 Schematic representation of the regenerating islet-derived type IV signaling pathway. Regenerating islet-derived type IV (RegIV) contributes to cell proliferation, inhibition of apoptosis, and carcinogenesis via protein kinase B (Akt) signaling pathway by transactivating the epidermal growth factor receptor (EGFR). The primary signaling pathway is now being investigated. MBS: Mannan-binding sites; PI3K: Phosphoinositide 3-kinase; PIP2: Phosphatidylinositol 4,5-bisphosphate; PIP3: Phosphatidylinositol 4,5-triphosphate; PDK1: Phosphoinositide-dependent kinase-1; Bcl-2: B-cell lymphoma 2.