Glypican-3 expression and its relationship with recurrence of HCC after liver transplantation

Figure 1 Receiver operating characteristic curve of glypican-3 mRNA levels for the detection of hepatocellular carcinoma. The area under the receiver operating characteristic curve is 0.878 (95% confidence interval: 0.802-0.953) (P < 0.001).

Figure 2 Hepatocellular carcinoma immunohistochemical staining (× 400). Glypican-3 expression in hepatocellular carcinoma by immunohistochemical analyses. A: Negative expression in HCC tissue; B: Weakly positive expression in HCC tissue; C: Positive expression in HCC tissue; D: Negative expression in adjacent non-neoplastic parenchyma. HCC: Hepatocellular carcinoma.

Figure 3 Kaplan-Meier survival curve for recurrence-free interval in 31 patients who underwent liver transplantation.

Figure 4 Kaplan-Meier survival curves for recurrence-free survival after liver transplantation for hepatocellular carcinoma. A: with or without glypican-3 mRNA overexpression (> 3.5 × 10^-2) (P = 0.034, compared by log-rank test); B: with or without glypican-3 protein expression (P = 0.231, compared by log-rank test).