Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Figure 1 Liver histology of rats fed a high-fructose diet for 5 wk. A: Hepatic steatosis, mainly distributed in zone 1, is observed (azan stain, × 40); B: Both macrovesicular and microvesicular steatosis are evident as well as scattered necroinflammatory foci (arrows) (hematoxylin and eosin stain, × 200).

Figure 2 Liver histology of rats fed a high-fructose diet + plant leaf extract. Hepatic fatty change is completely suppressed by the plant leaf extract (hematoxylin and eosin stain, × 40).