Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice

Figure 1 Representative pathological changes of liver section of the six groups (original magnification × 200). A: Section of liver from the vehicle control group showing a normal lobular structure; B: Section of liver from acetaminophen alone group showing large areas of centrilobular necrosis with inflammatory cell infiltration; C: Section of liver from the 12.5 mg/kg 5-methoxypsoralen (5-MOP) dose group showing absence of hepatocellular necrosis and infiltration of inflammatory cells but presence of hepatocellular hydropic degeneration and sinusoidal dilation; D: Section of liver from the 25 mg/kg 5-MOP dose group showing normal hepatocellular morphology but liver lobule structure damage; E: Section of liver from the 50 mg/kg 5-MOP dose group showing a significant alleviation of liver pathological injury with an almost normal lobular structure; F: Section of liver from 5-MOP alone group (50 mg/kg) showing presence of normal lobular structure.