Esophageal combined carcinomas: Immunohoistochemical and molecular genetic studies

Figure 1 Case 1. A: Endoscopy. An ulcerated tumor is seen in the esophagus; B: Histology of the squamous cell carcinoma element of the esophageal tumor. Keratinization is seen [hematoxylin and eosin (HE), x 200]; C: Small cell carcinoma element of the esophageal carcinoma. The tumor cells show characteristic morphologies of small cell carcinoma (HE, x 200); D: Cytokeratins are expressed in the small cell carcinoma component (x 200); E: Synaptophysin is expressed in the small cell carcinoma component (x 200); F: KIT is expressed in the small cell carcinoma component (x 200); G: Platelet-derived growth factor-α is expressed in the small cell carcinoma component (x 200).

Figure 2 Case 2. A: Endoscopy. An elevated tumor is seen in the esophagus; B: Histology of the squamous cell carcinoma element of the esophageal tumor. A cancer pearl is seen [hematoxylin and eosin (HE), x 200]; C: Small cell carcinoma element of the esophageal carcinoma. The tumor cells show characteristic morphologies of small cell carcinoma (HE, x 200); D: Adenocarcinomatous element shows focal tubular formations (HE, x 200); E: CD56 is expressed in the small cell carcinoma component (x 200); F: KIT is expressed in the small cell carcinoma component (x 200); G: Platelet-derived growth factor-α is expressed in the small cell carcinoma component (x 200).