Evaluation of Cladribine treatment in refractory celiac disease type II

Figure 1 Schematic representation of intracellular pathways involved in 2-CdA cytotoxicity. (Adapted with permission from Borak, 2006). 2-CdA-MP: Cladribine monophosphate; 2-CdA-DP: Cladribine diphosphate; 2-CdA-TP: Cladribine triphosphate; dCK: Deoxycytidine kinase; 5’-NT: 5’-nucleotidase; hENT: Human equilibrative nucleoside transporter; hCNT: Human concentrative nucleoside transporter; AIF: Apoptosis inducing factor; APAF-1: Apoptotic protease activating factor; PARP: Poly (ADP-ribose) polymerase.

Figure 2 Flowchart of the response to cladribine treatment. RCD: Refractory celiac disease; 2-CdA: 2-chlorodeoxyadenosine; auSCT: autologous hematopoietic stem cell transplantation; EATL: Enteropathy associated T-cell lymphoma.

Figure 3 Kaplan-Meier survival curves. A: Survival rate of responders and non-responders to cladribine treatment (Log Rank: P = 0.037). ¹3 patients died in the 1st and 5th year; ²1 patient died in the 2nd, 3rd and 4th year of follow-up; B: Survival rate of the pre-treatment (I) and the upfront 2-chlorodeoxyadenosine (II) group (Log Rank: P = 0.23). ¹4 patients died in the 1st year; ²1 patient died in the 1st, 3rd and 4th year; ³2 patients died in the 2nd year of follow-up.