Histone modifications and alcohol-induced liver disease: Are altered nutrients the missing link?

doi:10.3748/wjg.v17.i20.2465

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May 28, 2011 (publication date) through May 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2011; 17(20): 2465-2472
Published online May 28, 2011. doi: 10.3748/wjg.v17.i20.2465

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Figure 1 Nutrient disturbances, a potential link between alcohol metabolism and histone modifications in alcohol-induced liver disease. SAM: S-adenosylmethionine; NAD⁺: Nicotinamide adenine dinucleotide; HAT: Histone acetyltransferase; HDAC: Histone deacetylase; ALD: Alcohol-induced liver disease.

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Figure 2 S-adenosylmethionine metabolism in alcohol-induced liver disease. Effects of alcohol are indicated by dotted arrows; a: Methionine adenosyltransferase; b: Enzymes involved in transmethylation reactions; c: S-adenosylhomocysteine (SAH) hydrolase; d: Cystathionine-β-synthase; e: Betaine homecysteine methyltransferase; f: Methionine synthase; g: glutamate-cysteine synthetase; h: Glutathione (GSH) synthetase. SAM: S-adenosylmethionine; THF: Tetrahydrofolate.

Citation: Moghe A, Joshi-Barve S, Ghare S, Gobejishvili L, Kirpich I, McClain CJ, Barve S. Histone modifications and alcohol-induced liver disease: Are altered nutrients the missing link? World J Gastroenterol 2011; 17(20): 2465-2472
URL: https://www.wjgnet.com/1007-9327/full/v17/i20/2465.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i20.2465