Mechanism and dose-effect of Ginkgolide B on severe acute pancreatitis of rats

Figure 1 Pathological change of pancreatic tissues (HE staining, × 200). A: Sham-operation group; B: Severe acute pancreatitis group; C: DMSO group; D: 2.5 mg/kg BN52021 group; E: 5.0 mg/kg BN52021 group; F: 10 mg/kg BN52021 group; G: 20 μg/kg Sandostatin group.

Figure 2 Expression of platelet activating factor receptor mRNA in pancreatic tissues by reverse transcription polymerase chain reaction. 1: Marker; 2: Sham-operation group; 3: Severe acute pancreatitis group; 4: DMSO group; 5: 2.5 mg/kg BN52021 group; 6: 5.0 mg/kg BN52021 group; 7: 10 mg/kg BN52021 group; 8: 20 μg/kg Sandostatin group.

Figure 3 Expression of platelet activating factor receptor in pancreatic tissues by immunohistochemistry (HE staining, × 200). A: Sham-operation group; B: Severe acute pancreatitis group; C: DMSO group; D: 2.5 mg/kg BN52021 group; E: 5.0 mg/kg BN52021 group; F: 10 mg/kg BN52021 group; G: 20 μg/kg Sandostatin group.

Figure 4 Location of platelet activating factor receptor in pancreatic and lung tissues in sham-operation group shown by immunohistochemistry (HE staining, × 200). A: Paraffin slice of pancreatic tissues; B: Frozen slice of pancreatic tissues; C: Negative control of pancreatic tissues; D: Positive control of lung tissues.