Mallory-Denk Bodies in chronic hepatitis

Figure 1 Zone 1 distribution of Mallory-Denk Bodies in primary biliary cirrhosis (× 400). This distribution was observed in both early and later stages of primary biliary cirrhosis, such as cirrhosis.

Figure 2 Mallory-Denk Bodies, located perinuclear, has been shown as a larger picture in a patient with primary biliary cirrhosis (× 1000).

Figure 3 Mallory-Denk Bodies, located both perinuclear and intracytoplasmic, was observed in zone 1 in early stages of Wilson disease, but in every zone at the later stages, such as cirrhosis (× 400, 1000, respectively). Hydrophobic degeneration was more exaggerated. The diameter of Mallory-Denk Bodies was not homogenous in patients with Wilson disease.

Figure 4 Perinuclear location of Mallory-Denk Bodies in patients with hepatocellular carcinoma depends on the cause (× 1000). In this case, hepatitis B is responsible from Mallory-Denk Bodies.

Figure 5 Tiny and uniform Mallory-Denk Bodies was seen in patients with nonalcoholic steatohepatitis (× 1000).

Figure 6 Shows development of Mallory-Denk Bodies in ballooned hepatocytes. MDB: Mallory-Denk Bodies; HSPs: Heat shock proteins; HCC: Hepatocellular carcinoma.