Preparation, physicochemical characterization and cytotoxicity in vitro of gemcitabine-loaded PEG-PDLLA nanovesicles

Figure 1 Scanning electronic microphotographs of poly (ethylene glycol)-block-poly (D,L-lactide) (PEG-PDLLA) nanovesicles. A: × 40 000; B: × 20 000.

Figure 2 Transmission electron micrographs of PEG-PDLLA nanovesicles.

Figure 3 Release of gemcitabine from nanovesicles at pH 7. 4 and 5.0. Data are presented as mean ± SD. P < 0.05 at every point of pH 5.0 vs pH 7.4.

Figure 4 IC₅₀ of gemcitabine-loaded nanovesicles and free gemcitabine in human SW1990 pancreatic cancer cells. Data are presented as mean ± SD. ^aP < 0.05, ^cP > 0.05 vs free gemcitabine group.