Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients

Figure 1 Typical peri-nuclear staining showing anti-nuclear envelope antibody positive sera in indirect immunofluorescence. A: Cells fixed with 1% formaldehyde; B: Cells fixed with 4% formaldehyde.

Figure 2 Kaplan-Meier curve of survival between anti-nuclear envelope antibody negative and anti-nuclear envelope antibody positive patients (P = 0. 043 by Breslow test). ANEA: Anti-nuclear envelope antibody.

Figure 3 Causes of death between anti-nuclear envelope antibody positive and anti-nuclear envelope antibody negative patients (P = 0. 016). Anti-nuclear envelope antibody (ANEA) positive patients died more frequently of hepatic failure and/or hepatocellular carcinoma (HCC), while ANEA negative patients died more frequently as a result of variceal bleeding.

Figure 4 Kaplan-Meier curve of survival between anti-gp210 positive and anti-nuclear envelope antibody negative patients (P = 0. 009 by Breslow test). ANEA: Anti-nuclear envelope antibody.