Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: A meta-analysis

Figure 1 Relationship between alcohol dehydrogenase-1B*1/*1 and esophageal cancer stratified by alcohol consumption status. Weights are from random effects analysis. ¹Ex-drinkers mean alcohol quit for more than one year; ²Moderate drinkers mean consumers of 1-40 g/d alcohol (Lee 2008), 1-50 g ethanol < 5 d/wk (Yang 2005, Yang 2007), 1-60 g/d ethanol (Boonyaphiphat 2002), 1-17.9 units/wk and 1 unit = 22 g ethanol (Yokoyama 2002, Yokoyama 2006), and > 40 g alcohol/wk (Ding 2009); ³Heavy drinkers mean consumers of > 40 g/d alcohol (Lee 2008), > 50 g ethanol ≥ 5 d/wk (Yang 2005, Yang 2007), > 60 g/d ethanol (Chao 2000, Yokoyama 1996), > 18 units/wk (Yokoyama 2002, Yokoyama 2006[15]), and alcoholics (Yokoyama 2001, Yokoyama 2006[33]); ⁴Significant trend for meta-regression from never/rare drinkers to heavy drinkers is observed (P = 0.043). ADH1B: Alcohol dehydrogenase-1B.

Figure 2 Relationship between alcohol dehydrogenase-1B*1/*2 and esophageal cancer stratified by alcohol consumption status. Weights are from random effects analysis. ADH1B: Alcohol dehydrogenase-1B.

Figure 3 Relationship between aldehyde dehydrogenase-2*1/*2 and esophageal cancer stratified by alcohol consumption status. Weights are from random effects analysis. ¹Significant trend for meta-regression from never/rare drinkers to heavy drinkers is observed (P < 0.001). ALDH2: Aldehyde dehydrogenase-2.

Figure 4 Relationship between aldehyde dehydrogenase-2*2/*2 and esophageal cancer stratified by alcohol consumption status. Weights are from random effects analysis. ¹Ex-drinkers were excluded because there were no cases and controls with the ALDH2*2/*2 for this drinking status; ²Moderate and heavy drinkers were combined because of the small number of ALDH2*2/*2 drinkers. ALDH2: Aldehyde dehydrogenase-2.