Helicobacter pylori and EBV in gastric carcinomas: Methylation status and microsatellite instability

Figure 1 Example of results from methylation-specific PCR analysis performed in tumoral samples from patients with gastric cancer. The studied gene is given on the right of the each panel. Lane U: Amplified product with primers recognizing unmethylated sequences; Lane M: Amplified product with primers recognizing methylated sequences; L: Ladder 50 bp.

Figure 2 Frequencies of methylation at CDH1, DAPK, hMLH1, COX2 and CDKN2A genes in gastric carcinomas. A: Frequencies of methylation at CDH1, DAPK, hMLH1, COX2 and CDKN2A distributed according to tumor stages in diffuse adenocarcinoma; B: Frequencies of methylation at CDH1, DAPK, hMLH1, COX2 and CDKN2A distributed according to tumor stages in intestinal adenocarcinoma; C: Frequencies of methylation at CDH1, DAPK, hMLH1, COX2 and CDKN2A distributed with regard to age groups.