Heparanase and hepatocellular carcinoma: Promoter or inhibitor?

doi:10.3748/wjg.v16.i3.306

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Jan 21, 2010 (publication date) through Dec 31, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2010; 16(3): 306-311
Published online Jan 21, 2010. doi: 10.3748/wjg.v16.i3.306

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Figure 1 Heparan sulphate proteoglycan (HSPG) and fibroblast growth factor (FGF)-induced signal transduction. Basic FGF (bFGF) enhances tumor progression by protecting tumor cells from apoptosis. Cell surface HSPGs could act as a co-receptor for formation of a bFGF high-affinity receptor complex. The alteration of cell surface HSPGs resulting from heparanase might down-regulate HSPG-mediated bFGF-induced signal pathway, resulting in apoptosis of tumor cells.

Citation: Dong S, Wu XZ. Heparanase and hepatocellular carcinoma: Promoter or inhibitor? World J Gastroenterol 2010; 16(3): 306-311
URL: https://www.wjgnet.com/1007-9327/full/v16/i3/306.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i3.306