Antiproliferative effect of somatostatin analogs in gastroenteropancreatic neuroendocrine tumors

Figure 1 Chemical structure of the synthetic somatostatin analogs octreotide and lanreotide (adapted from[11]).

Figure 2 Somatostatin receptor-mediated effects on neuroendocrine cells (adapted from[23]).

Figure 3 Kaplan Meier curve demonstrating time to tumor progression in patients treated with octreotide long-acting repeatable (LAR) vs placebo[69]. Log-rank test stratified by functional activity: P = 0.000072, HR = 0.34 (95% CI: 0.20-0.59).