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Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Feb 21, 2009; 15(7): 804-816
Published online Feb 21, 2009. doi: 10.3748/wjg.15.804
Figure 1
Figure 1 Structures of the most abundant bile acids in humans, and their glycine and taurine conjugates.
Figure 2
Figure 2 Stereostructure of cholic acid. A: Space-filling model; B: Calculated molecular lipophilic potential[147]. Blue colour shows polar surface and red colour shows apolar surface; C: Cartoon representation (as introduced by Small[148]).
Figure 3
Figure 3 Schematic representation of bile acid synthesis by the classical neutral pathway. AKR1C4: 3α-hydroxysteroid dehydrogenase; AKR1D1: Δ4–3-oxosteroid-5β-reductase; AMACR: Alpha methylacyl-CoA racemase; BAAT: Bile acid; CoA: Amino acid N-acyltransferase (1A minor cytosolic fraction does also exist); BACS: Bile acid CoA synthetase; BCOX: Branched-chain acyl CoA oxidase; BDP: D-bifunctional protein hydratase; CYP27A1: Sterol 27-hydroxylase; CYP7A1: Cholesterol 7α-hydroxylase; CYP8B1: Sterol 12α-hydroxylase; HSD3B7: 3β-hydroxy-Δ5-C27-steroid dehydrogenase/isomerase; SCPx: Sterol carrier protein X; VLCS: Very long-chain acyl CoA synthetase; ER: Endoplasmic reticulum.