Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Nov 21, 2009; 15(43): 5377-5396
Published online Nov 21, 2009. doi: 10.3748/wjg.15.5377
Figure 1
Figure 1 Example of cluster plots for two SNPs. Plot A shows the plotting of the normalized intensity values for a SNP with good clustering. Each color represents the respective genotype (blue for GG, green for AG and red for AA). Plot B demonstrates the cluster plot for a SNP with bad clustering (same color coding as in A). Disease-associated SNPs demonstrating cluster plots as in B should be discarded as the significant associations at such SNPs are most likely technical artifacts.
Figure 2
Figure 2 Power calculations for different case-control study panel sizes. Power calculations for different case-control study panel sizes using an allelic based association test and a P-value of P < 5 × 10-7. All calculations assume a minor allele frequency of 30% and 1:2 ratio of cases vs controls.
Figure 3
Figure 3 Historical milestones in Crohn’s disease genetics. Developments in the knowledge of the genetics of Crohn’s disease. Only milestone gene discoveries are shown. With the publication of the Crohn’s disease meta-analysis in 2009 the number of replicated loci is now greater than 30.