Celecoxib-induced cholestatic liver failure requiring orthotopic liver transplantation

Figure 1 Hepatic histology. A: Relatively large portal tract containing bile ducts with increased nuclear to cytoplasmic ratio, eosinophilic transformation of the cytoplasm, nuclear hyperchromasia, and uneven nuclear spacing; B: Small portal tract containing the hepatic artery and portal vein, but there is no bile duct. Five of twelve interlobular portal tracts in this biopsy lacked bile ducts; C: Hepatectomy specimen: loss of interlobular bile ducts in most of the small portal tracts, more advanced portal and periportal fibrosis with short fibrous septa. (Haematoxylin & Eosin stain, × 100).