Polymorphism of thymidylate synthase gene associated with its protein expression in human colon cancer

Figure 1 Immunohistochemical detection of TS staining intensity on paraffin sections of colorectal carcinoma. A: Strong; B: moderate; C: Weak; D: Absent (× 200).

Figure 2 Electrophoresis of amplified products of patients with different TS TR genotypes: 220 bp (2R/2R), 248 bp (3R/3R) or both (2R/3R). Lane 1: 220 bp (2R/2R); Lane 2: 248 bp (3R/3R); Lane 3: 220 bp and 248 bp (2R/3R); M: molecular weight marker, a 100 bp ladder.

Figure 3 Distribution of TS polymorphisms.

Figure 4 Association of TS genotype with IRS of TS. IRS: Immunoreactivity score; TS: Thymidylate synthase.