Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers

Figure 1 Immunohistochemistry study of beta-catenin in CRC. A: Membranous staining pattern in normal colonic mucosa; B: Nuclear staining pattern and high OSD in a case with well differentiation histology; C: Nuclear and membranous staining pattern; D Membranous staining pattern; E Cytoplasmic staining pattern; F: Very weak staining intensity in a case of poorly differentiated CRC. (40 × magnification).

Figure 2 Kaplan-Meier survival curves and log-rank analysis. A: AJCC staging (P < 0.001); B: Tumor differentiation (P = 0.06); C: Metastatic status (P < 0.001); D: Nodal status (P < 0.001); E: Nuclear staining density (P = 0.59); F: Overall staining density (P < 0.001). Well: Well differentiation; mod: Moderate differentiation; poor: Poorly differentiation.