Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestine

Figure 1 TER (A) and short circuit current (I_sc) (B) in ischemic porcine ileum treated with lubiprostone and PEG 3350.

Figure 2 A: Mucosal-to-serosal flux of ³H-mannitol in porcine ileum. ^aP < 0.05 ischemia vs control, ischemia/lubiprostone; ^cP < 0.05 ischemia + PEG3350 vs control, ischemia, ischemia + lubiprostone; B: Mucosal-to-serosal flux of ¹⁴C-inulin in porcine ileum. ^eP < 0.05 ischemia vs control, ischemia/lubiprostone; ^gP < 0.05 ischemia + PEG3350 vs control, ischemia, ischemia/lubiprostone.

Figure 3 Light microscopic evaluation of ischemic intestinal tissues. A: Control (non-ischemic); B: Time 0 post-ischemia; C: Time 120-min post ischemia; D: Lubiprostone-time 120 min post-ischemia; E: -PEG 3350-time 120-min post-ischemia.

Figure 4 Morphometric evaluations of ischemic intestinal tissues. Villus height: ^aP < 0.05 control, ischemia time 0 min, lubiprostone vs ischemia time 120 min, PEG 3350; ^cP < 0.05 ischemia time 120 min vs all other groups; ^eP < 0.05 PEG 3350 vs all other groups; Villus width: ^aP < 0.05 control, ischemia time 0 min vs ischemia time 120 min, lubiprostone; ^cP < 0.05 ischemia time 120 min, lubiprostone vs all other groups.