Dendroaspis natriuretic peptide relaxes gastric antral circular smooth muscle of guinea-pig through the cGMP/cGMP-dependent protein kinase pathway

Figure 1 A: Effect of 10 nmol/L LY83583 on cGMP production of in tissue (n = 8), ^bP < 0. 01 vs control group, ^dP < 0.01 vs DNP group; B: Effect of 10 nmol/L LY83583 on cGMP production of in efflux (n = 8), ^fP < 0.01 vs control group, ^hP < 0.01 vs DNP group; C: Effect of a membrane-permeable PKG-specific inhibitor (KT5823) on DNP-induced inhibition of spontaneous contraction in gastric antral circular smooth muscle (n = 8), ^jP < 0.01 vs DNP group.

Figure 2 Effect of LY83583 on DNP-induced increase of I_K(Ca), ^bP < 0. 01 vs control group.

Figure 3 Effect of a membrane-permeable PKG-specific inhibitor, KT-5823, on DNP-induced increase of I_K(Ca) (n = 8), ^bP < 0. 01 vs control group.

Figure 4 A: Effect of a membrane-permeable PKG-specific inhibitor, KT-5823, on STOCs (n = 10); B: Effect of KT-5720 (500 nmol/L), a PKA-specific inhibitor, on STOCs (n = 10).