Enteral glutamine pretreatment does not decrease plasma endotoxin level induced by ischemia-reperfusion injury in rats

Figure 1 The effect of enteral Gln pretreatment (1 g/kg per day for four days) on intestinal permeability during I/R injury in rats. Intestinal I/R was induced by 60 min of occlusion, followed by 60 min of reperfusion. Changes in intestinal permeability were measured by urinary excretion of ⁵¹Cr-EDTA after its oral administration in rats. Data are expressed as means ± SEM. ^bP < 0.001 vs groupI, II and IV; ^dP < 0.001, vs groupsI, II and III.

Figure 2 The effect of enteral Gln pretreatment (1 g/kg per day for four days) on plasma endotoxin levels during I/R injury in rats. Intestinal I/R was induced by 60 min of occlusion, followed by 60 min of reperfusion. Changes in plasma endotoxin levels were measured by LAL test. Data are expressed as medians. ^bP < 0.001 vs groups I and II.

Figure 3 The effect of enteral Gln pretreatment (1 g/kg per day for four days) on histopathological changes during I/R injury in rats. Intestinal I/R was induced by 60 min of occlusion, followed by 60 min of reperfusion. Histopathological changes were scored by the “Chiu” intestinal ischemia scoring system. Data are expressed as medians. ^bP < 0.001 vs groups I and II.