Correlation of integrin β3 mRNA and vascular endothelial growth factor protein expression profiles with the clinicopathological features and prognosis of gastric carcinoma

Figure 1 In situ hybridization of integrin β3 mRNA. A: Negative expression in the plasma of non-tumor gastric mucosa (ISH, × 100); B: Positive expression in the plasma of gastric adenocarcinoma (ISH, × 200).

Figure 2 Immunohistochemical staining of VEGF. A: Negative staining in the cytoplasm of non-tumor gastric mucosa (EnVision, × 100); B: Positive staining in the cytoplasm of gastric adenocarcinoma with greater omentum infiltration (EnVision, × 200).

Figure 3 Microvessels in gastric cancer. A: Positive staining for CD34 in the vascular endothelial cells of gastric adenocarcinoma with MVD < 54.9/mm² (EnVision, × 400); B: Positive staining for CD34 in the vascular endothelial cells of gastric adenocarcinoma with MVD ≥ 54.9/mm² (EnVision, × 400).

Figure 4 Kaplan-Meier survival curves. A: Survival curves with positive and negative integrin β3 mRNA expression in gastric adenocarcinoma (P < 0.05); B: Survival curves with positive and negative VEGF expression in gastric adenocarcinoma (P < 0.05); C: Survival curves with MVD ≥ 54.90/mm² and < 54.90/mm² in gastric adenocarcinoma (P < 0.01).