Programmed death-1 expression is associated with the disease status in hepatitis B virus infection

Figure 1 PD-1 expression on CD8+ T cells in patients with acute exacerbation of hepatitis B (AEHB), chronic hepatitis B (CHB) and healthy controls (HC).

Figure 2 Comparison of PD-1 expression on CD8+ T cells in healthy controls (HC; 5. 8%), chronic hepatitis B (CHB; 12.7%), and acute exacerbation of hepatitis B (AEHB; 7.1%).

Figure 3 The number of HBV-specific CD8 T cells in CHB and AEHB patients.

Figure 4 The number of HBV-specific CD8 T cells in two patients with CHB (0. 07%) and AEHB (0.31%) respectively.

Figure 5 Significant inverse correlation between the number of HBV-specific CD8 T-cells and the level of PD-1 expression in patients with AEHB and CHB (R = 0. 541, P < 0.01).

Figure 6 Positive correlation between serum viral load and level of PD-1 expression on CD8+ T cells in patients with CHB and AEHB (R = 0. 272, P < 0.05).

Figure 7 Lack of significant correlation between PD-1 expression and serum ALT levels in the study patients (R = 0. 066, P > 0.05).