Cytomegalovirus infection in severe ulcerative colitis patients undergoing continuous intravenous cyclosporine treatment in Japan

Figure 1 Comparison of initial CMV detection by day among the three methods (Real-time PCR, CMV IgM, and HE stain).

Figure 2 Change in clinical symptoms (hematochezia and body temperature) between CMV-positive and CMV-negative UC patients during intravenous CyA treatment. Panel A showed the change in the degree of hematochezia. Panel B showed the change in body temperature. The mean values of each group were plotted. Symbols: ◆, CMV positive; ■, CMV negative. ^aP < 0.05.

Figure 3 Change in inflammation markers between CMV-positive and CMV-negative UC patients during intravenous CyA treatment. Panel A showed the change in WBC count. Panel B showed the change in CRP value. The mean values of each group were plotted. Symbols:◆, CMV positive; ■, CMV negative. ^aP < 0.05.

Figure 4 Change in liver function and renal function between CMV-positive and CMV-negative UC patients during intravenous CyA treatment. Panel A showed the change in liver function. The mean values of each group were plotted. Symbols: ◆, aspartate aminotransferase in CMV positive; ■, aspartate aminotransferase in CMV negative; ▲, alanine aminotransferase in CMV positive; ●, alanine aminotransferase in CMV negative. Panel B showed the change in renal function. The mean values of each group were plotted. Symbols: ◆, creatinine in CMV positive; ■, creatinine in CMV negative; ▲, blood urea nitrogen in CMV positive; ●, blood urea nitrogen in CMV negative, respectively. NS represented not significant.

Figure 5 Change in mean CMV IgM value and CMV viral DNA load after CMV infection. Panel A showed the change in mean CMV IgM value after infection. Panel B showed the change in mean CMV viral load after infection.