Antidiabetic effects of chitooligosaccharides on pancreatic islet cells in streptozotocin-induced diabetic rats

Figure 1 Chromatogram of chitooligosaccharids on Sephadex G-25 colum.

Figure 2 Effect of COS on proliferation of primary culture islet cells and βcell lines.

Figure 3 Photomicrograph of COS on the 48h proliferation of pancreatic islet cells and β cells (× 100) in control group (A) and 100 mg/L COS treatment group (B) of pancreatic islet cells, control group (C) and 100 mg/L COS treatment group (D) of β cell lines.

Figure 4 Effect of COS on growth phase of primary culture islet cells and β cell lines (A), insulin release from pancreatic islet cells (B), changes in 2 h plasma glucose (C), and in glucose tolerance test (D) after 60 d.