Targeting hepatitis B virus antigens to dendritic cells by heat shock protein to improve DNA vaccine potency

Figure 1 A: Comparison of T cell proliferation between different groups after stimulation with HBV protein (C57BL/6 mice); B: Comparison of T cell proliferation between stimulation with HBV protein and with non-related protein (Balb/c mice); C: Comparison of CTL activity to HBV protein pulsed target cells between different groups (C57BL/6 mice).

Figure 2 A: Comparison of T cell proliferation between different groups after stimulation with HBV classIpeptide (C57BL/6 mice); B: Comparison of CTL activity to HBV classIpeptide pulsed target cells between different groups (C57BL/6 mice); C: Comparison of T cell proliferation between stimulation with HBV and with non-related classI peptide (Balb/c mice); D: Comparison of CTL activity to HBV classIpeptide pulsed target cell between HBV and non-related classIpeptide (Balb/c mice).

Figure 3 A: Comparison of T cell proliferation between different groups after stimulation with HBV class II peptide (C57BL/6 mice); B: Comparison of T cell proliferation after stimulation with different class II peptide (Balb/c mice).

Figure 4 Comparison of CTL activity to target cells pulsed with different agents (Balb/c mice).

Figure 5 Comparison of antibody titers to HBV between different groups after immunization (Balb/c mice).

Figure 6 A: Tumor incidence after CT26-HBeAg challenge of Balb/c mice; B: Tumor growth after CT26-HBeAg challenge of Balb/c mice.