Pharmacogenomics in colorectal cancer: The first step for individualized-therapy

Figure 1 Chemical structure of the three most important drugs used in colorectal chemotherapy: 5-FU, CPT11 and Oxaliplatin.

Figure 2 Metabolism and mechanism of action of 5-fluoruracil (5-FU). The potential predictive markers for 5-FU response are in red-boxes.

Figure 3 Metabolism and mechanism of action of Irinotecan (CPT-11). The potential predictive markers for CPT-11 response are in red-boxes.

Figure 4 Mechanisms of action for the epidermal growth factor receptor and VEGF.

Figure 5 Combination of predictive gene sets for different therapies used in CRC.