Induction of apoptosis by artemisinin relieving the severity of inflammation in caerulein-induced acute pancreatitis

Figure 1 Representative HE-stained pancreatic tissue from the rats (original magnification × 40) in the control group (A), AP group (B) and artemisinin-treated group (C).

Figure 2 Isolated pancreatic acinar cells stained with AO and EB, and scanned under confocal laser microscope (original magnification × 100) in the control group (A), AP group (B), and artemisinin-treated group (C). Fine arrows indicate oncotic cells, and thick arrows indicate apoptotic cells.

Figure 3 Isolated pancreatic acinar cells stained with AO and EB, and observed under fluorescent microscope (original magnification × 40) in the control group (A), AP group (B), and artemisinin-treated group (C). Fine arrows indicate oncotic cells, and thick arrows indicate apoptotic cells.

Figure 4 Flow cytometric analysis of NF-κB activation in the control group (A), AP group (B), and artemisinin-treated group (C).

Figure 5 MIP-1α measured by Western blot and IL-1β mRNA detected by RT-PCR in the control group (A), AP group (B), and artemisinin -treated group (C).