Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis

Figure 1 Light microscopic changes of kidney (HE, ×400). A: 3-h model group showing protein cast in renal tubule; B and C: 6-h model group showing scattered degenerative necrosis in renal tubular epithelial cells, and renal interstitial edema, respectively; D: 12-h model group showing visible red cell cast.

Figure 2 Bax expression in different groups (×200). A: 12-h model group showing high (+++) Bax expression; B: 3-h Baicalin-treated with negative (-) Bax expression; C: 12-h model group showing moderate (++) Bax expression; D and E: 6-h octreotide-treated group showing mild (+) Bax expression.

Figure 3 Bcl-2 expression in different groups (× 200). A and B: 6-h model group showing high (+++) Bcl-2 expression; C: 6-h octreotide-treated group with negative (-) Bcl-2 expression.

Figure 4 Apoptosis in different groups (TUNEL, × 400). A: 6-h octreotide-treated group showing apoptosis of renal tubular epithelial cells; B: 6-h Baicalin-treated group showing apoptosis of renal tubular epithelial cells; C: 6-h model group with no (-) apoptosis; D: 6-h octreotide-treated group showing apoptosis of renal tubular epithelial cells.