Survivin: Potential role in diagnosis, prognosis and targeted therapy of gastric cancer

Figure 1 Survivin: from basic knowledge to clinicl application. A: the structure of surviving gene, mRNA and protein. The survivin gene is composed of exons 1-4, and produces a 16.5 kDa protein. B; Survivin has a dual function in apoptosis and mitotic progression; C: the proposal of modern gastric cancer diagnostic methodology and marker panel, with combination of the conventional diagnostic procedure and the new diagnostic methods. The latter was based on the examination of further molecular markers in less advanced stages of tumor and can be used for super-early diagnosis; D: the targeted therapy based on survivin nowadays.