Jejuno-jejunal invagination due to intestinal melanoma

Figure 1 Duodenum-jejunal distension and the presence of a jejunal loop with thickened walls, with a second hyper-dense image inside the same lumen, forming a target-shaped aspect characteristic of intestinal invagination.

Figure 2 Invagination at the third jejunal loop.

Figure 3 Presence of a hyperchromic ulcerated neoformation, with signs of recent bleeding of the serosa.

Figure 4 Ileal wall infiltrated with metastatic melanomatous cells with nuclear pseudoinclusions and nucleoli, in nest and trabecular arrangement (HE x 10).

Figure 5 Strong positivity at immunohistochemical assay for HMB45.