Expression and significance of intratumoral interleukin-12 and interleukin-18 in human gastric carcinoma

Figure 1 IL-12 and IL-18 expression in gastric cancer tissues (× 400). A: IL-12 expression appears predominantly in the cytoplasm of gastric cancer cells; B: IL-18 is present in both the cytoplasm and nuclei of gastric cancer cells.

Figure 2 The association between MVD and (A) IL-12, (B) IL-18. Boxes correspond to interquartile ranges. Lines in boxes represent the median values. The open circles represent the outliers.

Figure 3 Kaplan-Meier survival curves of patients with gastric cancer. A: IL-12-positive tumor has a significantly lower overall survival than those with IL-12-negative tumor (P = 0.002); B: The positive or negative expression of IL-18 shows no difference in overall survival (P = 0.342).