Ultrastructure of Kupffer cells and hepatocytes in the Dubin-Johnson syndrome: A case report

Figure 1 Several membrane-bound granules – varying in size, content, and electron density – located near the biliary pole of hepatocytes; broadening of granular endoplasmic reticulum (>); dilation of bile canaliculus (cb) with the loss of microvilli (×7 000).

Figure 2 Fragment of Kupffer cell with phagocytized thick black pigment granules; the cell adheres to a hepatocyte (H) containing a similar pigment deposit (×7 000).

Figure 3 A hypertrophic, evidently activated Kupffer cell with phagocytized, very thick, black pigment deposits and biliary lamellar material. The cell blocks the sinusoidal vascular lumen. Distinctly dilated Disse’s space contains a fine granular material (×4 400).