Sporadic ganglioneuromatosis of esophagogastric junction in a patient with gastro-esophageal reflux disorder and intestinal metaplasia

Figure 1 Initial endoscopic image of localized nodularity in esophageal mucosal surface with irregular Z-line.

Figure 2 Hematoxylin and eosin stained tissue section of biopsy from irregular EG-Junction showing neuroid proliferation within lamina propria (× 10).

Figure 3 Focal positivity for synaptophysin (insert × 10) confirms the presence of a neuronal (ganglio) component. S100 (× 20) confirms nerve sheath-neuromatous/neuromatosis component.