Colorectal Cancer
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 21, 2006; 12(35): 5644-5650
Published online Sep 21, 2006. doi: 10.3748/wjg.v12.i35.5644
Figure 1
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Figure 1 Time-course and dose-response effects of hemoglobin on apoptosis of colorectal cancer cell lines. A: HT-29 cell line. bP = 0.000 vs 0 μmol/L; B: Lovo cell line. bP = 0.000 vs 0 μmol/L; C: CCL-33Co cell line. bP = 0.000 vs 0 μmol/L.
Figure 2
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Figure 2 Flowcytometry of reactive oxygen species on HT-29 cells. A: After 3 h of hemoglobin administration; B: After 24 h of hemoglobin administration. a: Hb 0 μmol/L; b: Hb 10 μmol/L; c: Hb 50 μmol/L; d: Hb 100 μmol/L; e: Hb 250 μmol/L.
Figure 3
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Figure 3 Relative surviving fraction of cell lines at 24 h after simultaneously adding each concentration of 5-fluorouracil. A: HT-29 cell line. bP = 0.001 vs Control; B: Lovo cell line. bP = 0.003 vs Control; C: CCL-33Co cell line. aP = 0.039 vs Control.
Figure 4
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Figure 4 Relative surviving fraction of cell lines at 24 h after simultaneously adding each concentration of 5-DFUR. A: HT-29 cell line. bP = 0.001 vs Control; B: Lovo cell line. bP = 0.003 vs Control; C: CCL-33Co cell line. bP = 0.010 vs Control.
Figure 5
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Figure 5 Relative surviving fraction of cell lines after adding 5-FU (1 mg/L) and each concentration of hemoglobin. A: HT-29 cell line. bP = 0.004 vs Control; B: Lovo cell line. bP = 0.000 vs Control; C: CCL-33Co cell line. bP = 0.005 vs Control; D: Flowcytometry of HT-29 cell line. a: Hb 0 μmol/L; b: Hb 10 μmol/L; c: Hb 50 μmol/L; d: Hb 100 μmol/L; e: Hb 250 μmol/L.
Figure 6
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Figure 6 Relative surviving fraction of cell lines after adding 5-DFUR (1 mg/L) and each concentration of hemoglobin. A: HT-29 cell line. bP = 0.000 vs Control; B: Lovo cell line. bP = 0.006 vs Control; C: CCL-33Co cell line. bP = 0.000 vs Control; D: Flowcytometry of HT-29. a: Hb 0 μmol/L; b: Hb 10 μmol/L; c: Hb 50 μmol/L; d: Hb 100 μmol/L; e: Hb 250 μmol/L.
Figure 7
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Figure 7 Change of Prx1 expression after administration of hemoglobin. a: Hb 0 μmol/L; b: Hb 10 μmol/L; c: Hb 100 μmol/L; d: Hb 250 μmol/L.
Figure 8
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Figure 8 Change of SOD1 expression after administration of hemoglobin. a: Hb 0 μmol/L; b: Hb 10 μmol/L; c: Hb 50 μmol/L; d: Hb 100 μmol/L; e: Hb 250 μmol/L.