Medical treatment of cholestatic liver diseases: From pathobiology to pharmacological targets

doi:10.3748/wjg.v12.i28.4445

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Jul 28, 2006 (publication date) through Apr 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2006; 12(28): 4445-4451
Published online Jul 28, 2006. doi: 10.3748/wjg.v12.i28.4445

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Figure 1 Causes of cholestasis. PBC: Primary biliary cirrhosis; PFIC: Progressive familial intrahepatic cholestasis; PSC: Primary sclerosing cholangitis; VBDS: Vanishing bile duct syndrome. For details see text.

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Figure 2 Adaptive responses to cholestasis. BSEP: Bile salt export pump; CAR: Constitutive androstane receptor; CYP3A: Cytochrome P450 enzyme 3A; FXR: Farnesoid X receptor; OATP: Organic anion transporting polypeptide; OST: Organic solute transporter; MRP: Multidrug resistance associated protein; NTCP: Sodium taurocholate co-transporting polypeptide; PXR: Pregnane X receptor; SULT2A1: Sulphotranferase 2A1. For details see tect.

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Figure 3 Targets for medical treatment of intrahepatic cholestasis. BA: Bile acids. For details see text.

Citation: Paumgartner G. Medical treatment of cholestatic liver diseases: From pathobiology to pharmacological targets. World J Gastroenterol 2006; 12(28): 4445-4451
URL: https://www.wjgnet.com/1007-9327/full/v12/i28/4445.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i28.4445