Genetics of inflammatory bowel disease: The role of the HLA complex

Figure 1 Crohn's disease map of chromosome 6p and the HLA region. The IBD susceptibility locus IBD3 is here defined by a 34cM chromosomal bin (6.2), which reached genome wide significance for IBD in the genome scan meta-analysis of van Heel et al[10]. The IBD3 region encompasses the ~ 4MB HLA region shown in detail on the right of the figure. White, grey, striped and black boxes show expressed genes, gene candidates, non-coding genes and pseudogenes, respectively. Genes with polymorphisms associate with IBD are shown in red. Modified with permission from Shiina et al[61].