γ-aminobutyric acid secreted from islet β-cells modulates exocrine secretion in rat pancreas

Figure 1 Dose-dependent effects of glutamine on CCK-stimulated secretions of fluid (A) and amylase (B) in the isolated, perfused rat pancreas (mean ±  SE, n = 7). ^aP < 0.05 vs without glutamine.

Figure 2 Effects of bicuculline on glutamine- or GABA-enhanced, CCK-stimulated secretions of fluid (A) and amylase (B) in the isolated, perfused rat pancreas (mean ± SE, n = 7). ^aP < 0.05 vs without bicuculline.

Figure 3 Effects of glutamine on CCK-stimulated secretions of fluid (A) and amylase (B) in the pancreas isolated from the streptozotocin (STZ)-treated rat (mean ± SE, n = 7). ^aP < 0.05 vs STZ-treated pancreas.

Figure 4 Dose-dependent effects of glutamine on GABA secretion in the pancreas isolated from the normal rat (mean ± SE, n = 7). ^bP < 0.01 vs without glutamine.

Figure 5 Effects of gluta-mine on GABA secretion in the pancreas isolated from the streptozotocin-treated rat (mean ± SE, n = 7). ^aP < 0.05 vs normal pancreas.