Liver cirrhosis induced by long-term administration of a daily low dose of amiodarone: A case report

Figure 1 An unenhanced computed tomography (CT) scan of the upper abdomen. The liver has a greatly increased density (111.8 HU).

Figure 2 Microscopic features of the liver biopsy specimen. A: Micronodular cirrhosis has become established (silver impregnation, scale bar = 200 µm); B: Low power view of the liver biopsy specimen (hematoxylin and eosin stain, scale bar = 200 µm). Fatty degeneration and marked fibrosis with inflammatory cell infiltration were observed; C: High power view of the liver biopsy specimen (hematoxylin and eosin stain, scale bar = 20 µm). Foci of hepatocellular necrosis and dense fibrosis with neutrophilic infiltration were observed. Hepatocytes showed both the microvesicular and macrovesicular types of steatosis.

Figure 3 Transmission electron micrograph of the biopsy specimen with lamellated inclusions in the cytoplasm of the hepatocyte (original magnification ×20 000).