Effect of itopride, a new prokinetic, in patients with mild GERD: A pilot study

Figure 1 A: Change in mean heartburn score after treatment of itopride. The heartburn score of patients with GERD was improved in both groups of itopride significantly. ^bP < 0.0001, ¹P = 0.0006 vs pretreatment by paired t-test; B: Change in mean total symptom score after treatment of itopride. The mean total symptom score of patients with GERD was improved in both groups of itopride significantly. ^dP < 0.0001 vs pretreatment by paired t-test.

Figure 2 Change in mean number of acid refluxes after itopride treatment. Mean number of acid refluxes was significantly improved in 300-mg group. ¹P = 0.057 vs pretreatment by Wilcoxon’s signed rank test.

Figure 3 Change in mean level of prolactin after itopride treatment. The level of prolactin was not changed after treatment of itopride in GERD.