Effect of naked eukaryotic expression plasmid encoding rat augmenter of liver regeneration on acute hepatic injury and hepatic failure in rats

Figure 1 Electrophoresis pattern of recombinant pcDNA3-ALR plasmid digested by HindIII and EcoRI. Lane 1: PCR products of ALR cDNA; lanes 2 and 3: pcDNA3-ALR recombinant plasmid digested by HindIII and EcoRI; lanes 4 and 5: undigested pcDNA3-ALR recombinant plasmid; lane 6: DNA marker.

Figure 2 Histopathological alterations in rat liver tissue. A: Normal control group; B: model group of hepatic injury; C: IP injection group of 200 μg/kg pcDNA3-ALR; D: IV injection group of 200 µg/kg pcDNA3-ALR.

Figure 3 Expression of PCNA in rat hepatic tissue. A: Normal control group; B: model group of hepatic injury; C: IP injection group of 200 μg/kg pcDNA3-ALR; D: IV injection group of 200 µg/kg pcDNA3-ALR.