α-catenin expression is decreased in patients with gastric carcinoma

Figure 1 RT-PCR analysis of α-catenin mRNA in gastric tissues. Amplification of GAPDH mRNA was performed to ensure equal loading. Lanes 1 and 10: healthy controls; lane 6: tumor free; lanes 2-5, 7-9: tumor; M: marker.

Figure 2 Immunoreactivity of α-catenin in gastric carcinoma. A: Normal membranous staining pattern (SP ×400). B: Poorly differentiated tumors with complete loss of membranous staining in the majority of cells. Membranous staining can be seen in a few cells retaining gastric gland (SP ×200). C: Moderately differentiated tumors showing membranous staining pattern (SP ×200).