Sulindac induces apoptosis and protects against colon carcinoma in mice

Figure 1 Grade of the tissue lesions under microscopic examination. A: mild dysplasia (×100); B: moderate dysplasia (×100); C: severe dysplasia in model group (×200).

Figure 2 Macroscopic examination. A: Model-agent group (32^nd wk). Multiple nodes of tumors located in the large intestinal mucosa with the intestinal wall becoming thicker and rigid; B: Sulindac-preventative group (32^nd wk). Only two nodes of tumors of diameter about 2 mm are located at the large intestinal mucosa; C: Curative group (32^nd wk). Several nodes of tumor are located in the large intestinal mucosa with disappeared plica.

Figure 3 The distribution of proliferation and apoptotic cells. A: Model-agent group: there are a large number of positive cells with PCNA staining in large intestinal cancer and evenly distributed, ×200; B: Model-agent group: there are a small number of apoptotic cells in the large intestinal cancer. TUNEL, ×200; C: Curative group: there are a large number of apoptotic cells in the large intestinal cancer. TUNEL, ×200; D: Preventative group: there are a large number of apoptotic cells in the large intestinal cancer. TUNEL, ×200.