Gene expression profiling reveals sequential changes in gastric tubular adenoma and carcinoma in situ

Figure 1 Schematic view of amplification procedure.

Figure 2 Histologic view (left) and microdissected cells (right) of the normal gastric mucosa. (A) adenoma; (B) and carcinoma in situ; (C) (HE stain. ×20). Compared to adenomas, carcinoma in situ had only mild glandular complexity.

Figure 3 SAM analysis of gastric adenoma/carcinoma microdissected from formalin-fixed biopsies. A: At the expected false significance rate of 0.15%, 504 up-regulated and 29 down-regulated genes in adenoma/carcinoma vs normal control (Tables 2 and 3); B: At the expected false significance rate of 0.61%, 50 up-regulated and 22 down-regulated genes in carcinomas vs adenomas.

Figure 4 Selected genes of 9 groups showing the patterns of sequential expression changes. N: normal, A: adenoma, C: cancer.