Effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux

Figure 1 Photomicrographs of esophageal mucosa obtained using TEM of the suprabasal layer (original magnification, ×3500). DIS in erosive esophagitis before (A) and complete recovery after omeprazole treatment (B).

Figure 2 Effect of omeprazole therapy on the reduction of intercellular spaces (ICS) of esophageal mucosa in patients with NERD or erosive esophagitis. The dashed line represents the mean score of DIS which is the cut-off (0.74 µm) for damage.

Figure 3 Photomicrographs of esophageal mucosa obtained using TEM of the suprabasal layer (original magnification, ×3500) before (A) and after 3 mo (B) and 6 mo (C) of omeprazole treatment in the patient with persistence of DIS.