Ethnic difference of Helicobacter pylori gastritis: Korean and Japanese gastritis is characterized by male- and antrum-predominant acute foveolitis in comparison with American gastritis

Figure 1 Acute foveolitis. Note intense infiltration targeted to the proliferative zone of gastric pits (arrows). S: surface epithelium; P: proliferative zone; D: Deep glandular zone (H & E, ×150).

Figure 2 The prevalence of acute foveolitis in the populations. Antral acute foveolitis was most frequent in Koreans followed by Japanese and Americans (P<0.01). However, no difference was noted in the body. Topographically, Japanese and Koreans had antrum-predominant acute foveolitis (P<0.01), while no significant difference was noted between antrum and body in Americans (χ² test).

Figure 3 Interstitial neutrophilic infiltration. In the antrum, the overall prevalence was higher in Koreans, followed by Americans and Japanese (P<0.01). High-grade infiltration was in the order of Koreans, Japanese, and Americans (P<0.01). In the body, it was higher in Americans and Koreans than in Japanese (P<0.01). Grade 0: no infiltration; grade 1: mild degree; grade 2: moderate to severe degree infiltration.

Figure 4 Chronic interstitial inflammation. In the body, the prevalence of high-grade infiltration was higher in Americans than in Koreans and Japanese (P<0.01). In the antrum, no significant difference was present. Grade 1: mild degree; grade 2: moderate to severe degree infiltration.

Figure 5 Intestinal metaplasia. In the antrum, the prevalence of intestinal metaplasia was higher in Japanese and Koreans than in Americans (P<0.01). In the body, no significant difference was present. Grade 0: no infiltration; grade 1: mild degree; grade 2: moderate to severe degree infiltration.

Figure 6 Atrophy. In the antrum, the overall prevalence and intensity of atrophy was higher in Koreans than in Japanese and Americans (P<0.01). In the body, no significant difference was present. Grade 0: no infiltration; grade 1: mild degree; grade 2: moderate to severe degree infiltration.

Figure 7 Lymphoid follicle in the antrum and the body. In the body, the prevalence of lymphoid follicle was significantly higher in Americans than in other populations (P<0.001). No significant difference was present in the antrum.