Changes of inflammation-associated cytokine expressions during early phase of experimental endotoxic shock in macaques

Figure 1 Kinetics curves for TNF-α expression in macaque plasma (A) and. PBMCs (B) within 120 min after LPS administration. ^aP < 0.05 vs control group; ^bP < 0.01 vs control group.

Figure 2 Transcript levels of TNF-α mRNA in liver (A) and spleen (B) at 120 min after LPS administration. ^aP < 0.05 vs con-trol group, ^bP < 0.01 vs control group.

Figure 3 Dynamics of IL-1 β expression in macaque plasma (A) and PBMCs (B) within 120 min after LPS challenge. ^aP < 0.05 vs control group.

Figure 4 Transcript levels of IL-1 β mRNA in liver(A) and spleen(B) at 120 min after LPS administration. ^aP < 0.05 vs con-trol group.

Figure 5 The change of IL-18 mRNA transcript level in PBMCs within 120 min after LPS challenge. ^aP < 0.05 vs control group.

Figure 6 The levels of IL-18 mRNA transcript in liver (A) and spleen (B) at 120 min after LPS challenge. ^aP < 0.05 vs control group.

Figure 7 Change of plasma IL-12 levels within 120 min after LPS challenge. ^aP < 0.05 vs control group.

Figure 8 Change of plasma IL-10 level within 120 min after LPS injection. ^aP < 0.05 vs control group.

Figure 9 Identification of amplified products by RT-PCR with the method of agarose gel electrophoresis. A: 702 bp from TNF-α gene; B: 810 bp from IL-1 β gene; C: 341 bp from IL-18 gene; D: 225 bp from β -actin gene.

Figure 10 Differences of cDNA fragments from TNF-α (A), IL-1 β (B) and IL-18 (C) gene between macaque and human according to GenBank.