Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats

Figure 1 Effect of lansoprazole on the level of thiobarbituric-acid reactive substances (TBARS), mucosal mye-loperoxidase (MPO) activity, and cytolline induced meutrophil chemo-attracttant-1 (CINC-1) in intestinal mucosa of I/R-induced rats. A: Effect of lansoprazole on the level of TBARS in intestinal mucosa of I/R-induced rats. ^aP < 0.05 vs normal; ^cP < 0.05 vs control. Sham group and I/R group received an equivalent volume of vehicle instead of lansoprazole. B: Effect of lansoprazole on the level of mucosal myeloperoxidase (MPO) activities in intestinal mucosa of I/R-induced rats. ^aP < 0.05 vs normal; ^cP < 0.05 vs control. Sham group and I/R group received an equivalent volume of vehicle instead of lansoprazole. C: Effect of lansoprazole on cytokine induced neutrophil chemoattractant-1 (CINC-1) of intestinal mucosa of I/R-induced rats. ^aP < 0.05 vs normal; ^cP < 0.05 vs control. LAN(+): with lansoprazole; LAN(-): without lansoprazole.

Figure 2 Intestinal CINC-1 mRNA expression during I/R in rats. M: Marker; Lane 1: Before ischemia; Lane 2: After I/R; Lane 3: I/R + lansoprazole.